Reactome | DLD dimer dehydrogenates dihydrolipoyl

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DLD dimer dehydrogenates dihydrolipoyl Show undefined attributes

authored	[InstanceEdit:9859140] Stephan, Ralf, 2024-01-16
catalystActivity	[CatalystActivity:9859174] dihydrolipoyl dehydrogenase (NADH) activity of BCKDH [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9859173] Stephan, Ralf, 2024-01-16
crossReference	[DatabaseIdentifier:9853985] RHEA:15046
dbId	9859172
diseaseReaction	[FailedReaction:R-HSA-9907572] Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT - Homo sapiens
displayName	DLD dimer dehydrogenates dihydrolipoyl
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
eventOf	[Pathway:R-HSA-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Homo sapiens
followingEvent	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9859167] LipoH2-K105-DBT [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450848] Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations [LiteratureReference:9853970] Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism [LiteratureReference:9853977] Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components [LiteratureReference:9853975] Biochemical characterization of patients with dihydrolipoamide dehydrogenase deficiency
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DLD dimer dehydrogenates dihydrolipoyl
orthologousEvent	[Reaction:R-PFA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Plasmodium falciparum [Reaction:R-DDI-9859172] DLD dimer dehydrogenates dihydrolipoyl - Dictyostelium discoideum [Reaction:R-CEL-9859172] DLD dimer dehydrogenates dihydrolipoyl - Caenorhabditis elegans [Reaction:R-DME-9859172] DLD dimer dehydrogenates dihydrolipoyl - Drosophila melanogaster [Reaction:R-GGA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-XTR-9859172] DLD dimer dehydrogenates dihydrolipoyl - Xenopus tropicalis [Reaction:R-DRE-9859172] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio [Reaction:R-SSC-9859172] DLD dimer dehydrogenates dihydrolipoyl - Sus scrofa [Reaction:R-BTA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Bos taurus [Reaction:R-CFA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Canis familiaris [Reaction:R-RNO-9859172] DLD dimer dehydrogenates dihydrolipoyl - Rattus norvegicus [Reaction:R-MMU-9859172] DLD dimer dehydrogenates dihydrolipoyl - Mus musculus
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-70017] Lipo-K105-DBT [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9859163] DBT transfers BCAA to CoA - Homo sapiens [Reaction:R-HSA-5693153] PPM1K dephosphorylates p-BCKDH - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9907758] D'Eustachio, Peter, 2024-04-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9859172
summation	[Summation:9859254] Dihydrolipoyl dehydrogenase (DLD), the E3 component of the b...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9907572] Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT
(hasEvent)	[Pathway:R-HSA-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
(precedingEvent)	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV

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