Reactome | NNT dimer transfers proton from NADPH to NAD+

Schema > Reaction > Entries

NNT dimer transfers proton from NADPH to NAD+ Show undefined attributes

catalystActivity	[CatalystActivity:10366748] NAD(P)+ transhydrogenase (Si-specific) activity of NNT dimer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5462] mitochondrion
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10366750
displayName	NNT dimer transfers proton from NADPH to NAD+
eventOf	[Pathway:R-BTA-71403] Citric acid cycle (TCA cycle) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-450984] IDH2 dimer decarboxylates isocitrate - Bos taurus [Reaction:R-BTA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Bos taurus [Reaction:R-BTA-71401] OGDH dimer decarboxylates 2-OG - Bos taurus
inferredFrom	[Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	NNT dimer transfers proton from NADPH to NAD+ H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-450984] IDH2 dimer decarboxylates isocitrate - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-450971
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-BTA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-BTA-71401] OGDH dimer decarboxylates 2-OG [Reaction:R-BTA-450984] IDH2 dimer decarboxylates isocitrate
(inferredTo)	[Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+

Cite Us!