Reactome | acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

Schema > Reaction > Entries

acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ Show undefined attributes

catalystActivity	[CatalystActivity:10735722] 3-hydroxybutyrate dehydrogenase activity of BDH1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10735724
displayName	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+
eventOf	[Pathway:R-GGA-77111] Synthesis of Ketone Bodies - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-73909] ACA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ Reduction of Acetoacetate to beta-Hydroxybutyrate
output	[SimpleEntity:R-ALL-73911] bHBA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-74180] HMG CoA => acetoacetic acid + acetyl CoA - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-73912
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-77111] Synthesis of Ketone Bodies
(inferredTo)	[Reaction:R-HSA-73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

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