Reactome | SLC25A51 mediates mitochondrial uptake of NAD+

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SLC25A51 mediates mitochondrial uptake of NAD+ Show undefined attributes

catalystActivity	[CatalystActivity:10909732] NAD transmembrane transporter activity of SLC25A51 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10909734
displayName	SLC25A51 mediates mitochondrial uptake of NAD+
eventOf	[Pathway:R-DME-196807] Nicotinate metabolism - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A51 mediates mitochondrial uptake of NAD+ NAD(+)(in) = NAD(+)(out)
output	[SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9938195
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-DME-8955030] NADK2 dimer phosphorylates NAD+ to NADP+
(inferredTo)	[Reaction:R-HSA-9938195] SLC25A51 mediates mitochondrial uptake of NAD+

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