Reactome | SIRT3 deacetylates AcK-IDH2 dimer

Schema > Reaction > Entries

SIRT3 deacetylates AcK-IDH2 dimer Show undefined attributes

catalystActivity	[CatalystActivity:10520626] NAD-dependent protein lysine deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10552394
displayName	SIRT3 deacetylates AcK-IDH2 dimer
eventOf	[Pathway:R-SSC-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Homo sapiens
input	[Complex:R-SSC-9854462] AcK-IDH2 dimer [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SIRT3 deacetylates AcK-IDH2 dimer
output	2 × [SimpleEntity:R-ALL-5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix] [Complex:R-SSC-450982] IDH2 dimer [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-5688274] NAM [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-9854415] ACAT1 tetramer acetylates IDH2 dimer - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9854463
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(inferredTo)	[Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer

Cite Us!