Reactome | methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

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methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:9986653] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of ALDH6A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9986655
displayName	methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
eventOf	[Pathway:R-MMU-70895] Branched-chain amino acid catabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate - Mus musculus
inferredFrom	[Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-30004] 2M3OPROA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ (S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29896] HCO3- [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-70843] PROP-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-70893
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-MMU-71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate
(inferredTo)	[Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

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