Reactome | MDH2 dimer dehydrogenates MAL

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MDH2 dimer dehydrogenates MAL Show undefined attributes

catalystActivity	[CatalystActivity:11109557] L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11109559
displayName	MDH2 dimer dehydrogenates MAL
eventOf	[Pathway:R-PFA-9856872] Malate-aspartate shuttle - Plasmodium falciparum [Pathway:R-PFA-71403] Citric acid cycle (TCA cycle) - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-70975] CS acetylates OA to citrate - Plasmodium falciparum [Reaction:R-PFA-70613] GOT2 transaminates OA and L-Glu - Plasmodium falciparum [Reaction:R-PFA-71401] OGDH dimer decarboxylates 2-OG - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens
input	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	MDH2 dimer dehydrogenates MAL (S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
precedingEvent	[Reaction:R-PFA-376851] SLC25A11 exchanges 2-OG and MAL - Plasmodium falciparum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-70979
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-9856872] Malate-aspartate shuttle [Pathway:R-PFA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-PFA-71401] OGDH dimer decarboxylates 2-OG [Reaction:R-PFA-70975] CS acetylates OA to citrate [Reaction:R-PFA-70613] GOT2 transaminates OA and L-Glu
(inferredTo)	[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL