Reactome | IDH3 complex decarboxylates isocitrate

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IDH3 complex decarboxylates isocitrate Show undefined attributes

catalystActivity	[CatalystActivity:11081380] isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11081382
displayName	IDH3 complex decarboxylates isocitrate
eventOf	[Pathway:R-SCE-71403] Citric acid cycle (TCA cycle) - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-71401] OGDH dimer decarboxylates 2-OG - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate - Homo sapiens
input	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	IDH3 complex decarboxylates isocitrate D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-SCE-70971] ACO2 isomerizes citrate - Saccharomyces cerevisiae
regulatedBy	[Requirement:9986738] Requirement by 'ADP [mitochondrial matrix]' [NegativeRegulation:R-HSA-9012284] Negative regulation by 'ATP [mitochondrial matrix]' [NegativeRegulation:9986739] Negative regulation by 'NADH [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-70967
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-SCE-71401] OGDH dimer decarboxylates 2-OG
(inferredTo)	[Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate

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