Reactome | PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro Show undefined attributes

catalystActivity	[CatalystActivity:70663] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643684] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix] Functional specialization in proline biosynthesis of melanoma
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667668] RHEA:14107 [DatabaseIdentifier:9925790] RHEA:14107
dbId	70664
displayName	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
eventOf	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) - Homo sapiens
input	[SimpleEntity:R-ALL-113590] 1PYR-5COOH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6783923] Functional specialization in proline biosynthesis of melanoma [LiteratureReference:508083] Crystal structure of human pyrroline-5-carboxylate reductase [LiteratureReference:508064] Mutations in PYCR1 cause cutis laxa with progeroid features
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro 1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)
negativePrecedingEvent	[NegativePrecedingEvent:9930370] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
orthologousEvent	[Reaction:R-PFA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Plasmodium falciparum [Reaction:R-SCE-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Saccharomyces cerevisiae [Reaction:R-SPO-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Schizosaccharomyces pombe [Reaction:R-DDI-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Dictyostelium discoideum [Reaction:R-CEL-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Caenorhabditis elegans [Reaction:R-DME-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Drosophila melanogaster [Reaction:R-GGA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Gallus gallus [Reaction:R-XTR-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Xenopus tropicalis [Reaction:R-DRE-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Danio rerio [Reaction:R-SSC-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Sus scrofa [Reaction:R-BTA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Bos taurus [Reaction:R-CFA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Canis familiaris [Reaction:R-RNO-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Rattus norvegicus [Reaction:R-MMU-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Mus musculus
output	[SimpleEntity:R-ALL-379717] L-Pro [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70664
summation	[Summation:178924] Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the re...
updateTrackers	[UpdateTracker:9791183] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9784405] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v54:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9928431] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791183] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9784405] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v54:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9928431] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-HSA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)

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