Reactome | ALDH4A1 oxidizes 1PYR-3OH-5COOH

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ALDH4A1 oxidizes 1PYR-3OH-5COOH Show undefined attributes

catalystActivity	[CatalystActivity:10104783] L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10219943
displayName	ALDH4A1 oxidizes 1PYR-3OH-5COOH
eventOf	[Pathway:R-RNO-70688] Proline catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Homo sapiens
input	[SimpleEntity:R-ALL-9929425] 1PYR-3OH-5COOH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ALDH4A1 oxidizes 1PYR-3OH-5COOH (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH
output	[SimpleEntity:R-ALL-9929459] 4OH-L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-RNO-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9929439
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70688] Proline catabolism
(inferredTo)	[Reaction:R-HSA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH

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