Reactome | (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H

Schema > Reaction > Entries

(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H Show undefined attributes

catalystActivity	[CatalystActivity:10453205] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HADH dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10453258
displayName	(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H
eventOf	[Pathway:R-SSC-77352] Beta oxidation of butanoyl-CoA to acetyl-CoA - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Sus scrofa
inferredFrom	[Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Homo sapiens
input	[SimpleEntity:R-ALL-77251] 3HB-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H (3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)
output	[SimpleEntity:R-ALL-73871] ACA-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-77312
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-77352] Beta oxidation of butanoyl-CoA to acetyl-CoA
(precedingEvent)	[Reaction:R-SSC-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
(inferredTo)	[Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H

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