Reactome | methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+

Schema > Reaction > Entries

methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10428448] methylmalonate-semialdehyde dehydrogenase (acylating) activity of ALDH6A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10428450
displayName	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+
eventOf	[Pathway:R-DRE-70895] Branched-chain amino acid catabolism - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate - Danio rerio
inferredFrom	[Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-30004] 2M3OPROA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-70843] PROP-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Danio rerio
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-70893
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-DRE-71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate
(inferredTo)	[Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+