Reactome | MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF

Schema > Reaction > Entries

MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF Show undefined attributes

catalystActivity	[CatalystActivity:10721310] methenyltetrahydrofolate cyclohydrolase activity of MTHFD2, D2L [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10721312
displayName	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
eventOf	[Pathway:R-DME-196757] Metabolism of folate and pterines - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Homo sapiens
input	[SimpleEntity:R-ALL-5693984] 5,10-methylene-THF [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
output	[SimpleEntity:R-ALL-6801458] 5,10-methenyl-THF [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-DME-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6801328
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-DME-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF
(inferredTo)	[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF