Reactome | COQ7:COQ9 octamer hydroxylates DMQ10H2

Schema > Reaction > Entries

COQ7:COQ9 octamer hydroxylates DMQ10H2 Show undefined attributes

authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2167828] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
dbId	2162194
displayName	COQ7:COQ9 octamer hydroxylates DMQ10H2
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
eventOf	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2162186] COQ3 methylates DeMQ10H2 - Homo sapiens
input	[SimpleEntity:R-ALL-2162204] DMQ10H2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2167834] Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging [LiteratureReference:2167842] The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis [LiteratureReference:2167817] Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis [LiteratureReference:8933022] Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis [LiteratureReference:9856270] Structure and functionality of a multimeric human COQ7:COQ9 complex [LiteratureReference:9856314] Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function [LiteratureReference:9856303] ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption [LiteratureReference:9856341] Adolescence Onset Primary Coenzyme Q10 Deficiency With Rare CoQ8A Gene Mutation: A Case Report and Review of Literature [LiteratureReference:9856349] Clinical features and gene variation analysis of COQ8B nephropathy: Report of seven cases
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	COQ7:COQ9 octamer hydroxylates DMQ10H2 DMQ10H2 is hydroxylated to DeMQ10H2 by COQ7
orthologousEvent	[Reaction:R-DME-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Drosophila melanogaster [Reaction:R-SCE-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Saccharomyces cerevisiae [Reaction:R-SPO-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Schizosaccharomyces pombe [Reaction:R-DDI-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Dictyostelium discoideum [Reaction:R-GGA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Gallus gallus [Reaction:R-XTR-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Xenopus tropicalis [Reaction:R-DRE-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Danio rerio [Reaction:R-SSC-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Sus scrofa [Reaction:R-BTA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Bos taurus [Reaction:R-CFA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Canis familiaris [Reaction:R-RNO-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Rattus norvegicus [Reaction:R-MMU-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Mus musculus
output	[SimpleEntity:R-ALL-2162212] DeMQ10H2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-2162188] COQ5 methylates MDMQ10H2 - Homo sapiens
regulatedBy	[Requirement:9856304] Requirement by 'COQ8A,B:COQ7:COQ9 [mitochondrial inner membrane]'
regulationReference	[RegulationReference:9856309] Requirement by 'COQ8A,B:COQ7:COQ9 [mitochondrial inner membrane]' Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2162194
summation	[Summation:2167901] 5-Demethoxyubiquinone hydroxylase COQ7 catalyzes the hydroxy...

Referrals

(hasEvent)	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-HSA-2162186] COQ3 methylates DeMQ10H2

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