Reactome | ALDH5A1 dehydrogenates SUCCSA to SUCCA

Schema > Reaction > Entries

ALDH5A1 dehydrogenates SUCCSA to SUCCA Show undefined attributes

catalystActivity	[CatalystActivity:10591626] succinate-semialdehyde dehydrogenase (NAD+) activity of ALDH5A1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10591628
displayName	ALDH5A1 dehydrogenates SUCCSA to SUCCA
eventOf	[Pathway:R-GGA-916853] Degradation of GABA - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-70994] SDH complex dehydrogenates succinate - Gallus gallus
inferredFrom	[Reaction:R-HSA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix] [SimpleEntity:R-ALL-880046] SUCCSA [mitochondrial matrix]
isInDisease	false
isInferred	true
name	ALDH5A1 dehydrogenates SUCCSA to SUCCA Conversion of succinate semialdehyde to succinate
output	2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113536] SUCCA [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-888548
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-916853] Degradation of GABA
(precedingEvent)	[Reaction:R-GGA-70994] SDH complex dehydrogenates succinate
(inferredTo)	[Reaction:R-HSA-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA