Reactome | acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]

Schema > Reaction > Entries

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:71722] aldehyde dehydrogenase (NAD+) activity of ALDH2 tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9644480] aldehyde dehydrogenase (NAD) activity of ALDH2 tetramer [mitochondrial matrix] Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12668053] RHEA:25295
dbId	71723
deleted	[Deleted:449886] Deletion of instances: 142048, 71364
displayName	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-71384] Ethanol oxidation - Homo sapiens
followingEvent	[Reaction:R-HSA-449911] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] - Homo sapiens
input	[SimpleEntity:R-ALL-113532] CH3CHO [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71719] Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes [LiteratureReference:71366] Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. [LiteratureReference:449869] Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
orthologousEvent	[Reaction:R-SCE-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Saccharomyces cerevisiae [Reaction:R-SPO-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Schizosaccharomyces pombe [Reaction:R-DDI-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Dictyostelium discoideum [Reaction:R-CEL-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Caenorhabditis elegans [Reaction:R-DME-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Drosophila melanogaster [Reaction:R-GGA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Gallus gallus [Reaction:R-XTR-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Xenopus tropicalis [Reaction:R-DRE-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Danio rerio [Reaction:R-SSC-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Sus scrofa [Reaction:R-BTA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Bos taurus [Reaction:R-CFA-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Canis familiaris [Reaction:R-RNO-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Rattus norvegicus [Reaction:R-MMU-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Mus musculus
output	[SimpleEntity:R-ALL-113539] CH3COO- [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-449872] acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:449910] D'Eustachio, P, 2009-12-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71723
summation	[Summation:178365] ALDH2 (aldehyde dehydrogenase) in the mitochondrial matrix c...
updateTrackers	[UpdateTracker:9791612] Update Tracker - [Reaction:71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - v28:[addInput] [UpdateTracker:9790939] Update Tracker - [Reaction:71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - v32:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791612] Update Tracker - [Reaction:71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - v28:[addInput] [UpdateTracker:9790939] Update Tracker - [Reaction:71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - v32:[addLiteratureReference, add_removeInput, modifyText]
(replacementInstances)	[Deleted:449886] Deletion of instances: 142048, 71364
(hasEvent)	[Pathway:R-HSA-71384] Ethanol oxidation
(precedingEvent)	[Reaction:R-HSA-449911] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]

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