Reactome | PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Schema > Reaction > Entries

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro Show undefined attributes

catalystActivity	[CatalystActivity:10334563] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334565
displayName	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
eventOf	[Pathway:R-BTA-8964539] Glutamate and glutamine metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) - Bos taurus
inferredFrom	[Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens
input	[SimpleEntity:R-ALL-113590] 1PYR-5COOH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro 1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)
output	[SimpleEntity:R-ALL-379717] L-Pro [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-70664
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-BTA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
(inferredTo)	[Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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