Reactome | beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+

Schema > Reaction > Entries

beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10561629] 3-hydroxyisobutyrate dehydrogenase activity of HIBADH tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10561631
displayName	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
eventOf	[Pathway:R-DRE-70895] Branched-chain amino acid catabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Danio rerio
inferredFrom	[Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-573404] bHIBA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-2-methyl-3-oxopropanoate + H(+) + NADH
output	[SimpleEntity:R-ALL-30004] 2M3OPROA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-70885
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-DRE-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
(inferredTo)	[Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+

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