Reactome | SIRT3 deacetylates Ac-K272,K290-FOXO3

Schema > Reaction > Entries

SIRT3 deacetylates Ac-K272,K290-FOXO3 Show undefined attributes

catalystActivity	[CatalystActivity:10217696] protein lysine deacetylase activity of SIRT3(?-399) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10217698
displayName	SIRT3 deacetylates Ac-K272,K290-FOXO3
eventOf	[Pathway:R-RNO-9841251] Mitochondrial unfolded protein response (UPRmt) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9841812] FOXO3 translocates from the mitochondrial matrix to the nucleus - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-9841849] Foxo3 [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SIRT3 deacetylates Ac-K272,K290-FOXO3
output	2 × [SimpleEntity:R-ALL-5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix] [EntityWithAccessionedSequence:R-RNO-9841824] Foxo3 [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9841847
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9841251] Mitochondrial unfolded protein response (UPRmt)
(precedingEvent)	[BlackBoxEvent:R-RNO-9841812] FOXO3 translocates from the mitochondrial matrix to the nucleus
(inferredTo)	[Reaction:R-HSA-9841847] SIRT3 deacetylates Ac-K272,K290-FOXO3