Reactome | SIRT4 cleaves lipoyl from DLAT

Schema > Reaction > Entries

SIRT4 cleaves lipoyl from DLAT Show undefined attributes

catalystActivity	[CatalystActivity:10822501] lipoamidase activity of SIRT4:Zn2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10822503
displayName	SIRT4 cleaves lipoyl from DLAT
eventOf	[Pathway:R-GGA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9861626] SIRT4 cleaves lipoyl from DLAT - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-69969] DLAT [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SIRT4 cleaves lipoyl from DLAT
output	[SimpleEntity:R-ALL-9861625] 2''-O-lipoyl-ADP-D-ribose [mitochondrial matrix] [EntityWithAccessionedSequence:R-GGA-6792585] DLAT [mitochondrial matrix] [SimpleEntity:R-ALL-5688274] NAM [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Gallus gallus [Reaction:R-GGA-6807826] LDHAL6B reduces PYR to LACT - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9861626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-204174] Regulation of pyruvate dehydrogenase (PDH) complex
(inferredTo)	[Reaction:R-HSA-9861626] SIRT4 cleaves lipoyl from DLAT