Reactome | SIRT4 transfers ADPRib to GLUD

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SIRT4 transfers ADPRib to GLUD Show undefined attributes

catalystActivity	[CatalystActivity:10184536] NAD+ poly-ADP-ribosyltransferase activity of SIRT4:Zn2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10184538
displayName	SIRT4 transfers ADPRib to GLUD
eventOf	[Pathway:R-RNO-2151201] Transcriptional activation of mitochondrial biogenesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5688276] SIRT4 transfers ADPRib to GLUD - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-70582] GLUD1 [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SIRT4 transfers ADPRib to GLUD
output	[SimpleEntity:R-ALL-5688274] NAM [mitochondrial matrix] [EntityWithAccessionedSequence:R-RNO-5688244] phospho-RibC-GLUD1 [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5688276
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2151201] Transcriptional activation of mitochondrial biogenesis
(inferredTo)	[Reaction:R-HSA-5688276] SIRT4 transfers ADPRib to GLUD