Reactome | Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

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Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 Show undefined attributes

catalystActivity	[CatalystActivity:10237390] NADH dehydrogenase (ubiquinone) activity of Complex I [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10237402
displayName	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
eventOf	[Pathway:R-CFA-611105] Respiratory electron transport - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9864415] AAC1 imports a proton - Canis familiaris [Reaction:R-CFA-170026] UCP1 imports a proton - Canis familiaris [Reaction:R-CFA-164834] Enzyme-bound ATP is released - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:15809] mitochondrial electron transport, NADH to ubiquinone
inferredFrom	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Homo sapiens
input	[SimpleEntity:R-ALL-73663] CoQ [mitochondrial inner membrane] 5 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 NADH enters the respiratory chain at Complex I
output	[SimpleEntity:R-ALL-2162198] CoQH2 [mitochondrial inner membrane] 4 × [SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL - Canis familiaris [Reaction:R-CFA-70967] IDH3 complex decarboxylates isocitrate - Canis familiaris [Reaction:R-CFA-71401] OGDH dimer decarboxylates 2-OG - Canis familiaris [Reaction:R-CFA-450971] NNT dimer transfers proton from NADPH to NAD+ - Canis familiaris [Reaction:R-CFA-77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-CFA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Canis familiaris [Reaction:R-CFA-77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-CFA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Canis familiaris [Reaction:R-CFA-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-CFA-77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H - Canis familiaris [Reaction:R-CFA-77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H - Canis familiaris
regulatedBy	[PositiveRegulation:10237403] Positive regulation by 'COQ10A,B [mitochondrial inner membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-163217
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-611105] Respiratory electron transport
(precedingEvent)	[Reaction:R-CFA-164834] Enzyme-bound ATP is released [Reaction:R-CFA-9864415] AAC1 imports a proton [Reaction:R-CFA-170026] UCP1 imports a proton
(inferredTo)	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

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