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Entries
IDH3 complex decarboxylates isocitrate
Show undefined attributes
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catalystActivity
[CatalystActivity:70966] isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix]
catalystActivityReference
[CatalystActivityReference:9643803] isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix] Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
category
transition
compartment
[Compartment:5460] mitochondrial matrix
crossReference
[DatabaseIdentifier:9854202] RHEA:23633
[DatabaseIdentifier:11881001] Rhea:23633
dbId
70967
displayName
IDH3 complex decarboxylates isocitrate
eventOf
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent
[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens
[Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Homo sapiens
[Reaction:R-HSA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Homo sapiens
[Reaction:R-HSA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Homo sapiens
[Reaction:R-HSA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Homo sapiens
[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - Homo sapiens
input
[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix]
[SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:450990] Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase
[LiteratureReference:1165318] Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function
[LiteratureReference:198407] Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
[LiteratureReference:451003] Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
[LiteratureReference:450998] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
[LiteratureReference:9855610] Diphosphopyridine nucleotide dependent isocitrate dehydrogenase from pig heart. Charactgerization of the active substrate and modes of regulation
[LiteratureReference:9855605] Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
IDH3 complex decarboxylates isocitrate
D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH
orthologousEvent
[Reaction:R-GGA-373024] isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ - Gallus gallus
[Reaction:R-BTA-70967] IDH3 complex decarboxylates isocitrate - Bos taurus
[Reaction:R-CEL-70967] IDH3 complex decarboxylates isocitrate - Caenorhabditis elegans
[Reaction:R-SCE-70967] IDH3 complex decarboxylates isocitrate - Saccharomyces cerevisiae
[Reaction:R-DME-70967] IDH3 complex decarboxylates isocitrate - Drosophila melanogaster
[Reaction:R-SPO-70967] IDH3 complex decarboxylates isocitrate - Schizosaccharomyces pombe
[Reaction:R-SSC-70967] IDH3 complex decarboxylates isocitrate - Sus scrofa
[Reaction:R-DDI-70967] IDH3 complex decarboxylates isocitrate - Dictyostelium discoideum
[Reaction:R-CFA-70967] IDH3 complex decarboxylates isocitrate - Canis familiaris
[Reaction:R-RNO-70967] IDH3 complex decarboxylates isocitrate - Rattus norvegicus
[Reaction:R-MMU-70967] IDH3 complex decarboxylates isocitrate - Mus musculus
output
[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix]
[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix]
[SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-70971] ACO2 isomerizes citrate - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
regulatedBy
[Requirement:9853613] Requirement by 'ADP [mitochondrial matrix]'
[NegativeRegulation:9853611] Negative regulation by 'ATP [mitochondrial matrix]'
[NegativeRegulation:9853602] Negative regulation by 'NADH [mitochondrial matrix]'
regulationReference
[RegulationReference:9853617] Requirement by 'ADP [mitochondrial matrix]' Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised
[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70967
summation
[Summation:71416] Mitochondrial isocitrate dehydrogenase IDH3 catalyzes the ir...
Referrals
(precedingEvent)
[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG
[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2
[Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol
[Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol
[Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3-
[Reaction:R-HSA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria)
[Reaction:R-HSA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol)
[Reaction:R-HSA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane)
(hasEvent)
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
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