Reactome | methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+

Schema > Reaction > Entries

methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ Show undefined attributes

catalystActivity	[CatalystActivity:10334704] 3-hydroxyisobutyrate dehydrogenase activity of HIBADH tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10367951
displayName	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+
eventOf	[Pathway:R-BTA-70895] Branched-chain amino acid catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-30004] 2M3OPROA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (S)-2-methyl-3-oxopropanoate + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)
output	[SimpleEntity:R-ALL-573404] bHIBA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-508473
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-70895] Branched-chain amino acid catabolism
(inferredTo)	[Reaction:R-HSA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+

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