Reactome | ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate

Schema > Reaction > Entries

ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate Show undefined attributes

catalystActivity	[CatalystActivity:10733827] L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798258
displayName	ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate
eventOf	[Pathway:R-GGA-389661] Glyoxylate metabolism and glycine degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
inferredFrom	[Reaction:R-HSA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - Homo sapiens
input	[SimpleEntity:R-ALL-9929425] 1PYR-3OH-5COOH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH
output	[SimpleEntity:R-ALL-9929459] 4OH-L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-6784224] PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6784402
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-GGA-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)
(inferredTo)	[Reaction:R-HSA-6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate

Cite Us!