Reactome | (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H

Schema > Reaction > Entries

(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H Show undefined attributes

catalystActivity	[CatalystActivity:77282] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of Trifunctional Protein [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667497] RHEA:31160 [DatabaseIdentifier:9977442] RHEA:31160
dbId	77303
displayName	(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H
eventOf	[Pathway:R-HSA-77305] Beta oxidation of palmitoyl-CoA to myristoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77304] 3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA - Homo sapiens [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Homo sapiens
input	[SimpleEntity:R-ALL-77300] (S)-3-Hydroxyhexadecanoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77405] Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H (3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + NADH + H(+)
orthologousEvent	[Reaction:R-DRE-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Danio rerio [Reaction:R-CEL-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Caenorhabditis elegans [Reaction:R-DME-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Drosophila melanogaster [Reaction:R-GGA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Gallus gallus [Reaction:R-XTR-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Xenopus tropicalis [Reaction:R-SSC-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Sus scrofa [Reaction:R-BTA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Bos taurus [Reaction:R-CFA-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Canis familiaris [Reaction:R-RNO-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Rattus norvegicus [Reaction:R-MMU-77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H - Mus musculus
output	[SimpleEntity:R-ALL-77302] 3-Oxopalmitoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77301] trans-Hexadec-2-enoyl-CoA+H2O => (S)-3-Hydroxyhexadecanoyl-CoA - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77303
summation	[Summation:178248] Trifunctional protein in the mitochondrial matrix dehydrogen...
updateTrackers	[UpdateTracker:9984718] Update Tracker - [Reaction:77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984718] Update Tracker - [Reaction:77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-77305] Beta oxidation of palmitoyl-CoA to myristoyl-CoA
(precedingEvent)	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Reaction:R-HSA-77304] 3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA