Reactome | ALDH4A1 oxidises L-GluSS to Glu

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ALDH4A1 oxidises L-GluSS to Glu Show undefined attributes

catalystActivity	[CatalystActivity:10448806] L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10448808
displayName	ALDH4A1 oxidises L-GluSS to Glu
eventOf	[Pathway:R-SSC-70688] Proline catabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-70679] ALDH4A1 oxidises L-GluSS to Glu - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-31339] L-Glu5S [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ALDH4A1 oxidises L-GluSS to Glu H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+
output	2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70679
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-70688] Proline catabolism
(inferredTo)	[Reaction:R-HSA-70679] ALDH4A1 oxidises L-GluSS to Glu

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