Reactome | Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation

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Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation Show undefined attributes

authored	[InstanceEdit:109689] Gillespie, ME, 2004-01-19 00:00:00
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:109340] Gillespie, ME, 2004-01-02 00:00:00
dbId	109339
displayName	Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation
eventOf	[Pathway:R-HSA-77288] mitochondrial fatty acid beta-oxidation of unsaturated fatty acids - Homo sapiens
figure	[Figure:109982] /figures/unsatfattyacidbetao_1.jpg
followingEvent	[Reaction:R-HSA-109338] Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA - Homo sapiens [Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20426] fatty acid beta-oxidation
input	3 × [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-77359] LIN-CoA [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[Book:77402] The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR Mitochondrial fatty acid oxidation disorders 0079130356
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA
output	3 × [SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-77358] cis,cis-3,6-Dodecadienoyl-CoA [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
regulatedBy	[Requirement:R-HSA-5422852] Requirement by 'ACADL tetramer [mitochondrial matrix]' [Requirement:R-HSA-5422853] Requirement by 'Trifunctional Protein [mitochondrial matrix]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-109339
summation	[Summation:109983] Three cycles of beta oxidation, each mediated by the activit...

Referrals

(hasEvent)	[Pathway:R-HSA-77288] mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
(precedingEvent)	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 [Reaction:R-HSA-109338] Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA

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