Reactome | ME2 tetramer decarboxylates MAL to PYR

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ME2 tetramer decarboxylates MAL to PYR Show undefined attributes

authored	[InstanceEdit:9012269] Jassal, Bijay, 2017-07-12
catalystActivity	[CatalystActivity:9012261] malate dehydrogenase (decarboxylating) (NAD+) activity of ME2:Mg2+ tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9012269] Jassal, Bijay, 2017-07-12
crossReference	[DatabaseIdentifier:9862184] RHEA:12654 [DatabaseIdentifier:11880129] Rhea:12654
dbId	9012268
displayName	ME2 tetramer decarboxylates MAL to PYR
edited	[InstanceEdit:9012269] Jassal, Bijay, 2017-07-12
eventOf	[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
input	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012273] Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli [LiteratureReference:9012262] Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism [LiteratureReference:9012020] Structure and function of malic enzymes, a new class of oxidative decarboxylases [LiteratureReference:9012021] Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme [LiteratureReference:9012274] Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate [LiteratureReference:9012275] Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion [LiteratureReference:9012345] The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas [LiteratureReference:9861670] Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	ME2 tetramer decarboxylates MAL to PYR ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
orthologousEvent	[Reaction:R-CFA-9012268] ME2 tetramer decarboxylates MAL to PYR - Canis familiaris [Reaction:R-RNO-9012268] ME2 tetramer decarboxylates MAL to PYR - Rattus norvegicus [Reaction:R-MMU-9012268] ME2 tetramer decarboxylates MAL to PYR - Mus musculus [Reaction:R-BTA-9012268] ME2 tetramer decarboxylates MAL to PYR - Bos taurus [Reaction:R-SSC-9012268] ME2 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-DME-9012268] ME2 tetramer decarboxylates MAL to PYR - Drosophila melanogaster [Reaction:R-CEL-9012268] ME2 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans [Reaction:R-XTR-9012268] ME2 tetramer decarboxylates MAL to PYR - Xenopus tropicalis [Reaction:R-DRE-9012268] ME2 tetramer decarboxylates MAL to PYR - Danio rerio
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:R-HSA-9012256] Positive regulation by 'FUMA [mitochondrial matrix]' [NegativeRegulation:R-HSA-9012284] Negative regulation by 'ATP [mitochondrial matrix]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036107] Hung, Hui-Chih, 2018-01-30 [InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9012268
summation	[Summation:9012278] One hallmark of cancer is altered cellular metabolism. Malic...

Referrals

(hasEvent)	[Pathway:R-HSA-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-HSA-70501] PC carboxylates PYR to OA

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