Reactome | alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+

Schema > Reaction > Entries

alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10915962] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HSD17B10 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10915964
displayName	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+
eventOf	[Pathway:R-CEL-70895] Branched-chain amino acid catabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-70829] aMbHBUT-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH
output	[SimpleEntity:R-ALL-70836] 2MACA-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-70837
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-CEL-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
(inferredTo)	[Reaction:R-HSA-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+

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