Reactome | LDHAL6B reduces PYR to LACT

Schema > Reaction > Entries

LDHAL6B reduces PYR to LACT Show undefined attributes

catalystActivity	[CatalystActivity:10071710] L-lactate dehydrogenase (NAD+) activity of LDHAL6B [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10071712
displayName	LDHAL6B reduces PYR to LACT
eventOf	[Pathway:R-MMU-70268] Pyruvate metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9861626] SIRT4 cleaves lipoyl from DLAT - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:8716] lactate biosynthetic process from pyruvate
inferredFrom	[Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT - Homo sapiens
input	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	LDHAL6B reduces PYR to LACT
output	[SimpleEntity:R-ALL-6807616] LACT [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-9012016] FAHD1 dimer hydrolyses OA to PYR - Mus musculus [Reaction:R-MMU-9012349] ME3 tetramer decarboxylates MAL to PYR - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6807826
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-MMU-9861626] SIRT4 cleaves lipoyl from DLAT
(inferredTo)	[Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT