Reactome | SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

Schema > Reaction > Entries

SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 Show undefined attributes

catalystActivity	[CatalystActivity:10391390] NAD-dependent protein deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10391392
displayName	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2
eventOf	[Pathway:R-SSC-2151201] Transcriptional activation of mitochondrial biogenesis - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 - Homo sapiens
input	[DefinedSet:R-SSC-5688306] Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2 [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2
output	[SimpleEntity:R-ALL-5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix] [DefinedSet:R-SSC-5688291] ACCS2,GLUD,IDH2,SOD2 [mitochondrial matrix] [SimpleEntity:R-ALL-5688274] NAM [mitochondrial matrix]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5688289
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2151201] Transcriptional activation of mitochondrial biogenesis
(inferredTo)	[Reaction:R-HSA-5688289] SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

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