Reactome | saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

Schema > Reaction > Entries

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70937] saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity of AASS tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643995] saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity of AASS tetramer [mitochondrial matrix] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667576] RHEA:24521 [DatabaseIdentifier:9925997] RHEA:24521
dbId	70940
displayName	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-71064] Lysine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Homo sapiens [Reaction:R-HSA-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix] [SimpleEntity:R-ALL-30176] SACN [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70926] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities [LiteratureReference:70929] Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH AASS tetramer oxidises SACN to 2AMAS
orthologousEvent	[Reaction:R-MMU-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Mus musculus [Reaction:R-SCE-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Saccharomyces cerevisiae [Reaction:R-SPO-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Schizosaccharomyces pombe [Reaction:R-DDI-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Drosophila melanogaster [Reaction:R-DRE-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Danio rerio [Reaction:R-RNO-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Rattus norvegicus [Reaction:R-CFA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Canis familiaris [Reaction:R-BTA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Bos taurus [Reaction:R-GGA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Gallus gallus [Reaction:R-XTR-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Xenopus tropicalis [Reaction:R-SSC-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Sus scrofa
output	[SimpleEntity:R-ALL-113556] 2AMAS [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70940
summation	[Summation:179169] The saccharopine dehydrogenase activity of lysine-ketoglutar...
updateTrackers	[UpdateTracker:9790826] Update Tracker - [Reaction:70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - v32:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9790826] Update Tracker - [Reaction:70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - v32:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-HSA-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate [Reaction:R-HSA-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

Cite Us!