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Entries
ALDH4A1 oxidizes 1PYR-3OH-5COOH
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authored
[InstanceEdit:9929451] D'Eustachio, Peter, 2024-11-25
catalystActivity
[CatalystActivity:70678] L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
catalystActivityReference
[CatalystActivityReference:9929442] 1-pyrroline-5-carboxylate dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix] Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
crossReference
[DatabaseIdentifier:12667695] RHEA:31156
[DatabaseIdentifier:9929457] RHEA:31156
dbId
9929439
displayName
ALDH4A1 oxidizes 1PYR-3OH-5COOH
edited
[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
eventOf
[Pathway:R-HSA-70688] Proline catabolism - Homo sapiens
input
[SimpleEntity:R-ALL-9929425] 1PYR-3OH-5COOH [mitochondrial matrix]
2 ×
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:389852] Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta 1-pyrroline-3-hydroxy-5-carboxylate
[LiteratureReference:389804] Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
ALDH4A1 oxidizes 1PYR-3OH-5COOH
(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH
orthologousEvent
[Reaction:R-RNO-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Rattus norvegicus
[Reaction:R-GGA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Gallus gallus
[Reaction:R-XTR-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Xenopus tropicalis
[Reaction:R-DRE-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Danio rerio
[Reaction:R-SSC-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Sus scrofa
[Reaction:R-BTA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Bos taurus
[Reaction:R-CFA-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Canis familiaris
[Reaction:R-MMU-9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH - Mus musculus
output
[SimpleEntity:R-ALL-9929459] 4OH-L-Glu [mitochondrial matrix]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
[SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Homo sapiens
releaseDate
2025-03-26
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9939473] Hill, David P, 2025-02-27
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9929439
summation
[Summation:9929445] Mitochondrial ALDH4A1 catalyzes the reaction of 1PYR-3OH-5CO...
Referrals
(hasEvent)
[Pathway:R-HSA-70688] Proline catabolism
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