Reactome | Rotavirus

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Rotavirus Show undefined attributes

abbreviation	ROT
created	[InstanceEdit:5617435] Gillespie, Marc E, 2014-08-08
crossReference	[DatabaseIdentifier:5617434] NCBI Taxonomy:10912
dbId	5617433
displayName	Rotavirus
modified	[InstanceEdit:9014479] Weiser, JD
name	Rotavirus
schemaClass	Species
superTaxon	[Taxon:5643913] Sedoreovirinae
taxId	10912

Referrals

(superTaxon)

[Species:9615053] Rotavirus A

(relatedSpecies)

[Reaction:R-HSA-9921830] IFI6, IFI27 binds DDX58
[Complex:R-HSA-9921804] DDX58:DDX58 ligand:ATP:IFI6, IFI27 [mitochondrial outer membrane]
[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta
[Pathway:R-HSA-168898] Toll-like Receptor Cascades
[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade
[Pathway:R-HSA-168927] TICAM1, RIP1-mediated IKK complex recruitment
[Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex
[Reaction:R-HSA-9014343] IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
[Complex:R-HSA-9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane]
[Complex:R-HSA-9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane]
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex
[Pathway:R-HSA-9013957] TLR3-mediated TICAM1-dependent programmed cell death
[Reaction:R-HSA-9013963] RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
[CandidateSet:R-HSA-9013956] RIP3:TICAM1:activated TLR3 [endosome membrane]
[Complex:R-HSA-9013960] viral dsRNA:TLR3:TICAM1:RIPK3 [endosome membrane]
[Complex:R-HSA-9013961] viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane]
[CandidateSet:R-HSA-9013962] TICAM1:activated TLR3 complexes [endosome membrane]
[Reaction:R-HSA-9014320] SARM binds viral dsRNA:TLR3:TICAM1
[Complex:R-HSA-9014322] SARM:TICAM1:viral dsRNA:TLR3 [endosome membrane]
[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7
[Reaction:R-HSA-9013978] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
[Reaction:R-HSA-9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
[Reaction:R-HSA-9828205] TBK1 is phosphorylated within the activated TLR3 complex
[Complex:R-HSA-9828208] p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
[Complex:R-HSA-9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
[Complex:R-HSA-9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]
[BlackBoxEvent:R-HSA-9828200] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
[Complex:R-HSA-9830705] K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
[Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex
[Reaction:R-HSA-9828196] TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
[Complex:R-HSA-9828198] OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
[Complex:R-HSA-9828199] TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
[BlackBoxEvent:R-HSA-9830710] IKK? (IKBKE) is ubiquitinated within the activated TLR3 complex
[Complex:R-HSA-9830703] K63pUb-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
[Reaction:R-HSA-9830706] IKK? (IKBKE) is phosphorylated within the activated TLR3 complex
[Reaction:R-HSA-9828204] IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
[BlackBoxEvent:R-HSA-9013990] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
[Reaction:R-HSA-9013985] TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
[BlackBoxEvent:R-HSA-9013974] Auto-ubiquitination of TRAF3 within activated TLR3 complex
[Complex:R-HSA-9013980] TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
[Complex:R-HSA-9830708] p-S172-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
[Complex:R-HSA-9828203] IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
[Complex:R-HSA-9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
[Complex:R-HSA-9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane]
[Reaction:R-HSA-9013992] TRAF3 binds to TRIF:activated TLR3 complex
[Complex:R-HSA-9013984] TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
[Complex:R-HSA-9839013] EIF2AK2 dimer:Viral RNA activators [cytosol]
[Reaction:R-HSA-9013895] Caspase-8 processing within TLR3 complex
[Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly
[Complex:R-HSA-9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane]
[Complex:R-HSA-9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation
[Reaction:R-HSA-9705323] Phosphorylation of TBK1/IKBKE
[Reaction:R-HSA-9705145] TBK1, IKBKE form homodimers
[Reaction:R-HSA-933525] Phosphorylation and release of IRF7
[Reaction:R-HSA-933538] Recruitment of IRF7 to TRAF6
[Reaction:R-HSA-933527] Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
[Reaction:R-HSA-933537] Recruitment of TANK to TRAF6
[Complex:R-HSA-933479] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane]
[Complex:R-HSA-933470] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane]
[Complex:R-HSA-9705317] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane]
[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
[Reaction:R-HSA-933539] Recruitment of IKK complex
[Complex:R-HSA-933478] dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane]
[Complex:R-HSA-933473] viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane]
[Reaction:R-HSA-933532] Processing of caspases
[Reaction:R-HSA-933523] Dimerzation of procaspase-8, procaspase-10
[Reaction:R-HSA-933526] Recruitment of caspase-8 and -10 to FADD complex
[Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD
[Complex:R-HSA-933468] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
[Complex:R-HSA-8983916] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane]
[Complex:R-HSA-8983917] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane]
[Complex:R-HSA-933483] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
[Complex:R-HSA-918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane]
[Reaction:R-HSA-168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1
[Complex:R-HSA-177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]
[Reaction:R-HSA-933530] Activation of IKK by MEKK1
[Reaction:R-HSA-933528] Interaction of MEKK1 with TRAF6
[Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to MAVS
[Complex:R-HSA-933482] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane]
[Reaction:R-HSA-918229] Phosphorylation and release of IRF3/IRF7
[Reaction:R-HSA-918232] Recruitment of IRF3,IRF7
[Complex:R-HSA-918199] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane]
[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling
[BlackBoxEvent:R-HSA-936475] Negative regulation of DDX58/IFIH1 signaling by RNF216
[Reaction:R-HSA-936378] Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
[Complex:R-HSA-167985] viral dsRNA :TLR3 [endosome membrane]
[Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
[Complex:R-HSA-450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]
[Complex:R-HSA-177691] viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane]
[Complex:R-HSA-177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
[Complex:R-HSA-177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]
[Reaction:R-HSA-168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
[Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1)
[Reaction:R-HSA-177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
[BlackBoxEvent:R-HSA-450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
[Polymerisation:R-HSA-9628444] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
[Reaction:R-HSA-177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex
[Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex
[Complex:R-HSA-168906] 2x DDX58 ligand:2x DDX58:2xATP [cytosol]
[Complex:R-HSA-918190] 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol]
[DefinedSet:R-HSA-918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol]
[Complex:R-HSA-937325] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]
[Reaction:R-HSA-168935] viral dsRNA binds DDX58
[Reaction:R-HSA-918224] DDX58 is K63 polyubiquitinated
[Complex:R-HSA-918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane]
[Complex:R-HSA-918200] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane]
[Complex:R-HSA-918196] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane]
[Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
[Reaction:R-HSA-918227] Recruitment of TRAF3 to MAVS
[Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
[Complex:R-HSA-9705133] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
[Complex:R-HSA-933467] dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane]
[Complex:R-HSA-933472] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK [mitochondrial outer membrane]
[Complex:R-HSA-9705147] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane]
[Complex:R-HSA-9710999] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane]
[Reaction:R-HSA-9705137] TBK1 or IKBKE forms homodimers
[Reaction:R-HSA-9705320] TBK1, IKBKE are autophosphorylated at Ser172
[Complex:R-HSA-983462] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane]
[Reaction:R-HSA-990528] Interaction of PCBP2 with MAVS
[Reaction:R-HSA-937343] NLRC5 interacts with DDX58/IFIH1
[Complex:R-HSA-983461] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane]
[Complex:R-HSA-983459] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane]
[Reaction:R-HSA-990526] Recruitment of ITCH and K48 ubiquitination of MAVS
[Complex:R-HSA-936558] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane]
[Reaction:R-HSA-936381] OTUD5 deubiquitinates TRAF3
[Complex:R-HSA-936400] dsRNA:DDX58, IFIH1:MAVS:ATG5:ATG12 [mitochondrial outer membrane]

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