Reactome | Phosphorylation and release of IRF7

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Phosphorylation and release of IRF7 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:933524] protein serine/threonine kinase activity of dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
dbId	933525
displayName	Phosphorylation and release of IRF7
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-933533] Dimerization of p-IRF7 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-933470] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:918204] Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway
maxDepth	1
modified	[InstanceEdit:9835841] Shamovsky, Veronica, 2023-05-18
name	Phosphorylation and release of IRF7
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9705317] dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-450318] p-S477,S479-IRF7 [cytosol]
precedingEvent	[Reaction:R-HSA-933538] Recruitment of IRF7 to TRAF6 - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-933525
summation	[Summation:933438] IRF7 is activated through phosphorylation of residues Ser477...
updateTrackers	[UpdateTracker:9776346] Update Tracker - [Reaction:933525] Phosphorylation and release of IRF7 - v76:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776346] Update Tracker - [Reaction:933525] Phosphorylation and release of IRF7 - v76:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation
(precedingEvent)	[Reaction:R-HSA-933533] Dimerization of p-IRF7

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