Reactome | NLRC5 interacts with DDX58/IFIH1

Schema > Reaction > Entries

NLRC5 interacts with DDX58/IFIH1 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:937327] Garapati, P V, 2010-08-26
dbId	937343
displayName	NLRC5 interacts with DDX58/IFIH1
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-937324] NLRC5 [cytosol] [DefinedSet:R-HSA-918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:937326] NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
modified	[InstanceEdit:9835834] Shamovsky, Veronica, 2023-05-18
name	NLRC5 interacts with DDX58/IFIH1 NLRC5 interacts with RIG-I/MDA5 and inhibit IPS-1 binding
orthologousEvent	[Reaction:R-GGA-1227695] NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. - Gallus gallus
output	[Complex:R-HSA-937325] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-937343
summation	[Summation:937331] NLRC5 competes with IPS-1 for binding to the CARD domain of ...

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(hasEvent)

[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling

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