Reactome | TLR3-induced ripoptosome assembly

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TLR3-induced ripoptosome assembly Show undefined attributes

authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013896] Shamovsky, Veronica, 2017-07-26
dbId	9013889
displayName	TLR3-induced ripoptosome assembly
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
eventOf	[Pathway:R-HSA-9013957] TLR3-mediated TICAM1-dependent programmed cell death - Homo sapiens
followingEvent	[Reaction:R-HSA-9013895] Caspase-8 processing within TLR3 complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-54639] FADD [cytosol] [Complex:R-HSA-177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:448684] Caspase-activation pathways in apoptosis and immunity [LiteratureReference:2562571] dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8 [LiteratureReference:2423825] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways [LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:2584562] The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR3-induced ripoptosome assembly
output	[Complex:R-HSA-9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
precedingEvent	[Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013889
summation	[Summation:9013894] TRIF (also known as TICAM1) was repored to efficiently induc...

Referrals

(hasEvent)	[Pathway:R-HSA-9013957] TLR3-mediated TICAM1-dependent programmed cell death
(precedingEvent)	[Reaction:R-HSA-9013895] Caspase-8 processing within TLR3 complex