Reactome | TBK1 is phosphorylated within the activated TLR3 complex

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TBK1 is phosphorylated within the activated TLR3 complex Show undefined attributes

authored	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId	9828205
displayName	TBK1 is phosphorylated within the activated TLR3 complex
edited	[InstanceEdit:9863258] Shamovsky, Veronica, 2024-02-28
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
followingEvent	[Reaction:R-HSA-9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9828199] TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:9827948] The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
maxDepth	1
modified	[InstanceEdit:9863520] Shamovsky, Veronica, 2024-03-01
name	TBK1 is phosphorylated within the activated TLR3 complex TBK1 is phosphorylated within K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9828208] p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
precedingEvent	[Reaction:R-HSA-9828196] TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 - Homo sapiens
regulatedBy	[PositiveRegulation:9828206] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]'
regulationReference	[RegulationReference:9828207] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]' The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863280] Muniti?, Ivana, Franjki?, Toni, 2024-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9828205
summation	[Summation:9828195] TANK-binding kinase I (TBK1) and its close homolog inhibitor...

Referrals

(hasEvent)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7
(precedingEvent)	[Reaction:R-HSA-9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3

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