Reactome | activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane]

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activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-HSA-9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9014343] IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex - Homo sapiens
created	[InstanceEdit:9014345] Shamovsky, Veronica, 2017-07-28
dbId	9014344
displayName	activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-937021] K63polyUb-RIPK1 [cytosol] [Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:165954] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
maxDepth	5
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	activated TLR3:TICAM1:K63pUb-RIP1 viral dsRNA:TLR3:TICAM1:K63pUb-RIP1
producedByEvent	[Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9014344
updateTrackers	[UpdateTracker:9898154] Update Tracker - [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9898909] Update Tracker - [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - v64:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9898154] Update Tracker - [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9898909] Update Tracker - [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - v64:[updateContainedComponent]
(output)	[Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex
(hasComponent)	[Complex:R-HSA-9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane]
(input)	[Reaction:R-HSA-9014343] IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex

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