Reactome | viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]

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viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-HSA-9013961] viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly - Homo sapiens [Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens
created	[InstanceEdit:177648] Gillespie, ME, 2006-04-03 18:35:27
dbId	177649
displayName	viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-450326] RIPK1 [endosome membrane] [Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
inDisease	false
includedLocation	[Compartment:171907] endosome lumen
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:165954] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	viral dsRNA:TLR3:TICAM1:RIPK1 viral dsRNA:TLR3:TRIF:RIP1
positivelyRegulates	[PositiveRegulation:R-HSA-975228] Positive regulation by 'viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]'
producedByEvent	[Reaction:R-HSA-168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-177649

Referrals

(input)	[Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex [Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly
(hasComponent)	[Complex:R-HSA-9013961] viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane]
(hasCandidate)	[CandidateSet:R-HSA-9013962] TICAM1:activated TLR3 complexes [endosome membrane]
(output)	[Reaction:R-HSA-168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1
(regulator)	[PositiveRegulation:R-HSA-975228] Positive regulation by 'viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]'

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