Reactome | Phosphorylation and release of IRF3/IRF7

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Phosphorylation and release of IRF3/IRF7 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:918231] protein serine/threonine kinase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:918228] Garapati, P V, 2010-08-02
dbId	918229
displayName	Phosphorylation and release of IRF3/IRF7
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7 - Homo sapiens [Reaction:R-HSA-1028821] Dimerization of Phospho IRF3 or phospho IRF7 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-918199] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:918204] Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:433975] Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical [LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch
maxDepth	1
modified	[InstanceEdit:9835840] Shamovsky, Veronica, 2023-05-18
name	Phosphorylation and release of IRF3/IRF7
orthologousEvent	[Reaction:R-GGA-1227881] Phosphorylation and release of IRF3 - Gallus gallus
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Complex:R-HSA-9710999] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-918232] Recruitment of IRF3,IRF7 - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-918229
summation	[Summation:918166] Human IRF3 is activated through a two-step phosphorylation i...
updateTrackers	[UpdateTracker:9776322] Update Tracker - [Reaction:918229] Phosphorylation and release of IRF3/IRF7 - v76:[add_removeOutput] [UpdateTracker:9782055] Update Tracker - [Reaction:918229] Phosphorylation and release of IRF3/IRF7 - v59:[modifyText] [UpdateTracker:9789572] Update Tracker - [Reaction:918229] Phosphorylation and release of IRF3/IRF7 - v37:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776322] Update Tracker - [Reaction:918229] Phosphorylation and release of IRF3/IRF7 - v76:[add_removeOutput] [UpdateTracker:9782055] Update Tracker - [Reaction:918229] Phosphorylation and release of IRF3/IRF7 - v59:[modifyText] [UpdateTracker:9789572] Update Tracker - [Reaction:918229] Phosphorylation and release of IRF3/IRF7 - v37:[modifyText]
(precedingEvent)	[Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7 [Reaction:R-HSA-1028821] Dimerization of Phospho IRF3 or phospho IRF7
(hasEvent)	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway

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