Reactome | Recruitment of TRAF3 to MAVS

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Recruitment of TRAF3 to MAVS Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:918228] Garapati, P V, 2010-08-02
dbId	918227
displayName	Recruitment of TRAF3 to MAVS
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-936381] OTUD5 deubiquitinates TRAF3 - Homo sapiens [Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-936402] K63polyUb-TRAF3 [cytosol] [Complex:R-HSA-918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:918158] Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif [LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:918205] Antiviral signaling through pattern recognition receptors
modified	[InstanceEdit:9835849] Shamovsky, Veronica, 2023-05-18
name	Recruitment of TRAF3 to MAVS
orthologousEvent	[BlackBoxEvent:R-GGA-1227893] TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex - Gallus gallus [Reaction:R-GGA-1227891] TRAF3/or TRAF6 interacts with IPS-1 - Gallus gallus
output	[Complex:R-HSA-918200] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-918227
summation	[Summation:918146] TRAF3 a E3 ligase for K63-linked polyubiquitination, is one ...

Referrals

(hasEvent)	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway
(precedingEvent)	[Reaction:R-HSA-936381] OTUD5 deubiquitinates TRAF3 [Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3