Reactome | viral dsRNA:TLR3:TICAM1 [endosome membrane]

Schema > Complex > Entries

viral dsRNA:TLR3:TICAM1 [endosome membrane] Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-HSA-177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] - Homo sapiens [Complex:R-HSA-9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] - Homo sapiens [Complex:R-HSA-9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane] - Homo sapiens [Complex:R-HSA-9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-5602624] Defective TRAF3 does not transmit the signal - Homo sapiens [Reaction:R-HSA-9014320] SARM binds viral dsRNA:TLR3:TICAM1 - Homo sapiens [Reaction:R-HSA-9013992] TRAF3 binds to TRIF:activated TLR3 complex - Homo sapiens [Reaction:R-HSA-168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - Homo sapiens [Reaction:R-HSA-177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 - Homo sapiens
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
dbId	168907
deleted	[Deleted:9910833] Deletion of instance: 2201340
displayName	viral dsRNA:TLR3:TICAM1 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-450316] TICAM1 [endosome membrane] [Complex:R-HSA-167985] viral dsRNA :TLR3 [endosome membrane]
inDisease	false
includedLocation	[Compartment:171907] endosome lumen
literatureReference	[LiteratureReference:2428862] Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta
maxDepth	4
memberOf	[CandidateSet:R-HSA-9013962] TICAM1:activated TLR3 complexes [endosome membrane] - Homo sapiens
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	viral dsRNA:TLR3:TICAM1 viral dsRNA:TLR3:TRIF
producedByEvent	[Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - Homo sapiens [Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-168907
updateTrackers	[UpdateTracker:9892745] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v54:[updateContainedComponent] [UpdateTracker:9898089] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9868789] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, updateContainedComponent] [UpdateTracker:9871004] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9870824] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v38:[modifyName, updateContainedComponent] [UpdateTracker:9897324] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v62:[addName, updateContainedComponent] [UpdateTracker:9872885] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9898823] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v64:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9892745] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v54:[updateContainedComponent] [UpdateTracker:9898089] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9868789] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, updateContainedComponent] [UpdateTracker:9871004] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9870824] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v38:[modifyName, updateContainedComponent] [UpdateTracker:9897324] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v62:[addName, updateContainedComponent] [UpdateTracker:9872885] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9898823] Update Tracker - [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] - v64:[updateContainedComponent]
(replacementInstances)	[Deleted:9910833] Deletion of instance: 2201340
(input)	[FailedReaction:R-HSA-5602624] Defective TRAF3 does not transmit the signal [Reaction:R-HSA-9014320] SARM binds viral dsRNA:TLR3:TICAM1 [Reaction:R-HSA-9013992] TRAF3 binds to TRIF:activated TLR3 complex [Reaction:R-HSA-168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 [Reaction:R-HSA-177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
(hasComponent)	[Complex:R-HSA-9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] [Complex:R-HSA-9013960] viral dsRNA:TLR3:TICAM1:RIPK3 [endosome membrane] [Complex:R-HSA-9014322] SARM:TICAM1:viral dsRNA:TLR3 [endosome membrane] [Complex:R-HSA-9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] [Complex:R-HSA-9013984] TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] [Complex:R-HSA-9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane] [Complex:R-HSA-9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-HSA-177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] [Complex:R-HSA-177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] [Complex:R-HSA-450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]
(hasMember)	[CandidateSet:R-HSA-9013962] TICAM1:activated TLR3 complexes [endosome membrane]
(output)	[Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) [Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex

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