Reactome | IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3

Schema > Reaction > Entries

IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 Show undefined attributes

authored	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId	9828204
deleted	[Deleted:9863259] Deletion of instance: 9013986
displayName	IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
edited	[InstanceEdit:9863258] Shamovsky, Veronica, 2024-02-28
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9830710] IKK? (IKBKE) is ubiquitinated within the activated TLR3 complex - Homo sapiens [Reaction:R-HSA-9830706] IKK? (IKBKE) is phosphorylated within the activated TLR3 complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-450225] IKBKE [cytosol] [Complex:R-HSA-9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:9832593] Increased IKK? protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency
maxDepth	1
modified	[InstanceEdit:9863512] Shamovsky, Veronica, 2024-03-01
name	IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
orthologousEvent	[Reaction:R-GGA-433804] IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex - Gallus gallus
output	[Complex:R-HSA-9828203] IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9013990] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863280] Muniti?, Ivana, Franjki?, Toni, 2024-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9828204
summation	[Summation:9828197] Pathogen-induced inflammatory signaling pathways lead to the...

Referrals

(replacementInstances)	[Deleted:9863259] Deletion of instance: 9013986
(hasEvent)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7
(precedingEvent)	[BlackBoxEvent:R-HSA-9830710] IKK? (IKBKE) is ubiquitinated within the activated TLR3 complex [Reaction:R-HSA-9830706] IKK? (IKBKE) is phosphorylated within the activated TLR3 complex

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