Reactome | TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:9014563] ubiquitin-protein transferase activity of TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[BlackBoxEvent:R-HSA-9013974] Auto-ubiquitination of TRAF3 within activated TLR3 complex - Homo sapiens
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
dbId	9013984
displayName	TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-914241] TRAF3 [cytosol] [Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
isChimeric	false
literatureReference	[LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 [LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	TRAF3:TICAM1:viral dsRNA:TLR3 TRAF3:TRIF:activated TLR3
producedByEvent	[Reaction:R-HSA-9013992] TRAF3 binds to TRIF:activated TLR3 complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9013984

(input)	[BlackBoxEvent:R-HSA-9013974] Auto-ubiquitination of TRAF3 within activated TLR3 complex
(physicalEntity)	[CatalystActivity:9014563] ubiquitin-protein transferase activity of TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
(output)	[Reaction:R-HSA-9013992] TRAF3 binds to TRIF:activated TLR3 complex