Reactome | Recruitment of ITCH and K48 ubiquitination of MAVS

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Recruitment of ITCH and K48 ubiquitination of MAVS Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:990525] ubiquitin protein ligase activity of ITCH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:990524] Garapati, P V, 2010-11-03
dbId	990526
displayName	Recruitment of ITCH and K48 ubiquitination of MAVS
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-975995] ITCH [cytosol] [Polymer:R-HSA-912740] K48polyUb [cytosol] [Complex:R-HSA-983462] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:983448] PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
maxDepth	1
modified	[InstanceEdit:9835846] Shamovsky, Veronica, 2023-05-18
name	Recruitment of ITCH and K48 ubiquitination of MAVS
orthologousEvent	[Reaction:R-GGA-1227860] ITCH homolog downregulates MDA5/IPS1 signaling - Gallus gallus
output	[Complex:R-HSA-983459] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-990528] Interaction of PCBP2 with MAVS - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-990526
summation	[Summation:983444] On viral infection PCB2 binds MAVS (IPS-1) and recruits the ...
updateTrackers	[UpdateTracker:9928517] Update Tracker - [Reaction:990526] Recruitment of ITCH and K48 ubiquitination of MAVS - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928517] Update Tracker - [Reaction:990526] Recruitment of ITCH and K48 ubiquitination of MAVS - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling

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