Reactome | Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)

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Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:171907] endosome lumen
created	[InstanceEdit:168093] Gillespie, ME, 2005-11-10 16:29:25
dbId	168092
diseaseReaction	[FailedReaction:R-HSA-5602549] Defective TLR3 does not bind viral dsRNA - Homo sapiens
displayName	Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
edited	[InstanceEdit:2129343] Shamovsky, V, 2012-02-19
eventOf	[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-2000341] TLR3 [endosome membrane] [DefinedSet:R-NUL-9038432] TLR3 ligand [endosome lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:177856] Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 [LiteratureReference:434101] Structural basis of toll-like receptor 3 signaling with double-stranded RNA
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Viral dsRNA binds the Toll-Like Receptor 3 (TLR3)
output	[Complex:R-HSA-167985] viral dsRNA :TLR3 [endosome membrane]
relatedSpecies	[Species:5617433] Rotavirus [Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168092
summation	[Summation:433801] Viral dsRNA triggers an antiviral pathway mediated by toll l...
updateTrackers	[UpdateTracker:9780690] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v62:[add_removeInput] [UpdateTracker:9842222] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v86:[modifyText] [UpdateTracker:9790937] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v32:[addLiteratureReference, add_removeInput, add_removeSummation] [UpdateTracker:9779815] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v64:[add_removeInput] [UpdateTracker:9784293] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v54:[add_removeInput] [UpdateTracker:9788726] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v40:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9780690] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v62:[add_removeInput] [UpdateTracker:9842222] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v86:[modifyText] [UpdateTracker:9790937] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v32:[addLiteratureReference, add_removeInput, add_removeSummation] [UpdateTracker:9779815] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v64:[add_removeInput] [UpdateTracker:9784293] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v54:[add_removeInput] [UpdateTracker:9788726] Update Tracker - [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - v40:[add_removeInput]
(normalReaction)	[FailedReaction:R-HSA-5602549] Defective TLR3 does not bind viral dsRNA
(hasEvent)	[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade
(precedingEvent)	[Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1)

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