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Entries
Activation of recruited TAK1 within the activated TLR3 complex
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authored
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity
[CatalystActivity:450212] MAP kinase kinase kinase kinase activity of viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created
[InstanceEdit:177688] Gillespie, ME, 2006-04-04 05:49:12
dbId
177692
displayName
Activation of recruited TAK1 within the activated TLR3 complex
edited
[InstanceEdit:450363] Shamovsky, V, 2009-12-16
eventOf
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex - Homo sapiens
followingEvent
[Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:450183] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
[LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses
[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Activation of recruited TAK1 within the activated TLR3 complex
orthologousEvent
[Reaction:R-GGA-433957] Activation of recruited TAK1 - Gallus gallus
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-177691] viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane]
precedingEvent
[Reaction:R-HSA-177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - Homo sapiens
relatedSpecies
[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
revised
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-177692
summation
[Summation:9014311] TAK1 complex consists of transforming growth factor-beta (TG...
Referrals
(hasEvent)
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex
(precedingEvent)
[Reaction:R-HSA-847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex
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