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Schema
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Reaction
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Entries
Phosphorylated TAK1 dissociates from the TLR3 receptor complex
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authored
[InstanceEdit:765399] Shamovsky, V, 2010-05-21
category
dissociation
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:847072] Shamovsky, V, 2010-05-28
dbId
847070
displayName
Phosphorylated TAK1 dissociates from the TLR3 receptor complex
edited
[InstanceEdit:765399] Shamovsky, V, 2010-05-21
eventOf
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex - Homo sapiens
followingEvent
[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Homo sapiens
[Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Homo sapiens
[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
input
[Complex:R-HSA-177691] viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
[LiteratureReference:169927] Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Phosphorylated TAK1 dissociates from the TLR3 receptor complex
orthologousEvent
[Reaction:R-GGA-921145] Activated chicken TAK1 dissociates from the activated TLR3 complex - Gallus gallus
output
[Complex:R-HSA-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol]
[Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
precedingEvent
[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex - Homo sapiens
relatedSpecies
[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:844686] Gillespie, ME, 2010-05-28
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-847070
summation
[Summation:847071] Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leav...
Referrals
(hasEvent)
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex
(precedingEvent)
[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6
[Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7
[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex
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